Caprion

Accelerating precision medicine™

Pharmacokinetics

Caprion applies its expertise in proteomics and development of quantitative assays to support PK studies. Our MRM mass spectrometry-based assays provide robust, accurate and precise quantitation of a target protein (biotherapeutic) in biological matrices. We also apply our expertise in mass spectrometry to comprehensive analysis of both the large and small molecule components of Antibody-Drug Conjugates (ADCs). Caprion has a strong track record for developing custom assays requiring complex sample preparation and mass spectrometry analysis.

Applications

  • Absolute quantitation of target protein, including those that may be difficult to perform with standard immunoassays
  • Multiplexed assays for concomitant analysis of biotherapeutic and PD markers
  • Characterization of ADCs, including total antibody, conjugated antibody, free drug and distribution of drug-to-antibody ratio (DAR)


Benefits of Caprion’s MRM-based PK Assays

Caprion provides custom assay development for biotherapeutics, as well as assay transfer or adaptation, assay validation and analysis of study samples.

  • High selectivity, including differentiation of isoforms and of endogenous vs. biotherapeutic protein
  • Simultaneous detection and quantitation of multiple peptides of biotherapeutic
  • Option for antibody-free or antibody-assisted approach
  • Assay validation and analysis of study samples in a GLP environment, in compliance with FDA and EMEA guidelines on bioanalytical method validation.

 


Caprion

Accreditations & Certifications

CAP accreditation and CLIA certification

CAP Accredited

Headquarters

+1 514.360.3600
+1 877.776.3443
141 President Kennedy Ave., Suite SB-5658
Montreal, Quebec
CANADA

USA

Primity Bio
48383 Fremont Blvd
Suite 118
Fremont, CA 94538
Tel.: +1 858.229.2529

Serametrix
2235 Farraday Ave,Suite N,
Carlsbad, CA, 92008, USA
Tel: +1 760 652 4060

HistoGeneX
1331 W 75th St #401,
Naperville, IL 60540, USA
Tel: +1 630-473-6655
info@histogenex.com

AUSTRALIA

Serametrix Party Limited
Suite 4/54-60 Briggs Street
Camperdown, NSW, 2050
Australia
+61 2 9168 5908

EUROPE

Caprion Biosciences Inc.
+32 (0) 71 96 23 36
8 rue Adrienne Bolland
6041 Gosselies
BELGIUM

Serametrix
Unit 22, Surrey Technology Centre,
40 Occam Road,
Guildford, Surrey, UK
GU2 7YG
Tel: +44 1483 685599

Antwerp, Belgium
HistoGeneX
Sint-Bavostraat 78
2610 Antwerpen (Wilrijk)
Belgium
Tel: +32 3 50 20 500
Sample Reception: +32 3 50 20 620
Shipments: +32 3 50 20 625

CANADA LAB

201 President Kennedy Ave., Suite PK-3900
Montreal, Quebec
CANADA
+1 514.360.3600
+1 877.776.3443



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Contact

+1 877.776.3443

info@caprion.com