Caprion

Finding proteins that hit the mark

Career Opportunities

Corporate culture

Caprion offers a dynamic and stimulating work environment, encouraging continuous innovation and the sharing of knowledge and ideas. We are proud to have built a strong team of highly motivated and skilled people.

We believe our success depends on the contributions and dedication of each employee. We are looking for individuals who are motivated by challenges and have the skills needed to evolve themselves and the company into the future.

Our world-class proteomics facility is situated within the Science Pavillion building of UQAM (Université de Québec à Montréal) in downtown Montréal.

Opportunities

 

DIRECTOR OF BIOINFORMATICS


In this role as Director of Bioinformatics (BI), reporting to the Vice-President, Scientific Operations, you will lead Caprion’s bioinformatics/statistics group and will be a team player with leadership skills and experience.

Responsibilities:

  • Overall team supervision ;
  • Team development including individual team member coaching, goal setting, technical mentorship and enforcement of best practices;
  • Developing and implementing workflows as well as tools to process and manage data in an effective and timely manner;
  • Organizing and leading the team to ensure a robust and scalable platform;
  • Developing and implementing training programs for staff to build an environment of high performance;
  • Providing accurate estimation of bioinformatics/statistics effort for projects based on scope of work;
  • Proper allocation of resources to staff projects appropriately;
  • Directing the work of staff applying bioinformatics/statistical tools;
  • Collaborating with Study Directors and Process Leaders to ensure that project objectives are met and are completed on time;
  • Ensuring effective communication within and across teams as well as Caprion sites (Menlo Park and Montreal);
  • Keeping abreast of new bioinformatics/statistical tools and software for proteomic analysis;
  • Recommending new systems and processes to improve current proteomic platform;
  • Testing new and updated bioinformatics/statistical tools and software;
  • Collaborating with software developers in the development and modification of commercial bioinformatics software;
  • Developing and delivering presentations and updates for senior management and Caprion customers;

Requirements:

  • The qualified individual will possess a Ph.D. in Biostatistics, Bioinformatics, Computer Science or related field, along with 5+ years of experience in the Bioinformatics field and 3+ years of direct management experience in life sciences.
  • Direct experience with “Omics” data analysis is an asset and knowledge of biomarkers and clinical drug development is a plus.
  • Works closely with business management and charting a cogent Bioinformatics strategy at the scientific level, including designing the enabling technology/information management solutions and leading their successful execution.
  • You should have the ability to integrate different perspectives and deliver enterprise-wide strategic impact; with a successful track record in a sophisticated technology organization, preferably in a research-intensive and entrepreneurial environment.
  • You need a broad business and scientific perspective, not just technical knowledge;
  • Excellent problem solving abilities, communication and interpersonal skills; a keen ability to lead and motivate and superb management and strategic planning skills.
  • Demonstrated ability to manage multiple short and long-term projects of varying complexity with flexibility in a dynamic environment where priorities are changing.
  • A strong results-oriented work ethic is required to ensure on-time high quality delivery of products to customers.
  • Abilities to build consensus and partnership around issues that help the organization thrive in a competitive biotechnology environment will be put to good use.

 

SENIOR SCIENTIST SAMPLE PROCESSING / MASS SPECTROMETRY


Caprion is seeking a highly motivated individual with experience in protein chemistry/mass spectrometry/protein characterization to join a collaborative, proteomics focused scientific environment. Caprion’s leading and proprietary proteomics discovery technologies - ProteoCarta™ - enable the discovery of novel targets for therapeutics development and the identification of novel protein biomarkers that can significantly reduce risk and enhance clinical development productivity and decision making in pharmaceutical research. Caprion is based in Montreal, Canada and is looking to fill a Senior Scientist position as described below:

The focus will be on conducting label-free differential quantification and identification of protein biomarkers using the Thermo QExactive as well as conducting MRM-based assays for marker verification and validation, using the Ab Sciex QTRAP systems. This individual will work independently but closely with proteomics and bioinformatics scientists in a results-driven, collaborative environment. He/she will be responsible for the choice of experimental methodology, carrying out the analyses and providing interpretations and conclusions from the results in a report for each project in a timely fashion. The successful candidate will also advise the scientific team on general biomarker discovery questions, platform design, study design, and data analysis. The Senior Scientist is expected to propose and implement new sample analysis procedures and/or improve existing ones. You will train RAs to support your biomarker discovery experiments with abundant protein depletion, SCX and High-pH RP chromatography for sample fractionation as well as sample preparation following standard operating procedures.

Responsibilities:

  • Perform sample preparation for a variety of biological materials.
  • Perform mass spectrometry analysis and interpret results to ensure validity of conclusions.
  • Hands-on experience in operating a variety of electrospray-based LC/MS systems with a high comfort level.
  • Responsible for method development both discovery and quantitative method. Ability to also perform method development and validation of PK assay of biomarker(s) and drug products such as biologics/biosimilars
  • Perform in-depth data analysis and interpretation for each experiment
  • Provide clear presentation and summary of analysis results and biological interpretation.
  • Design and execute experimental testing
  • Design and execute troubleshooting experiments
  • Propose and implement novel approaches to sample processing and mass spectrometry analysis.
  • Train Research Associate to perform new sample preparation or analytical techniques.
  • Provide scientific recommendations to improve the quality of results and the platform.
  • Monitor data quality and take responsibility for project execution in the laboratory.
  • Must be capable of working in a GLP environment

Skills Requirements:

  • M.Sc. or Ph.D in life sciences, chemistry or biochemistry (or equivalent).
  • A minimum of 5 years of relevant experience.
  • Prioritize, organize workload and meet deadlines in a fast-paced, changing environment.
  • Capable of supervision for specific projects will be an asset.
  • May require working in BSL2 environment.
  • Solid understanding of mass spectrometry, molecular biology, protein chemistry.
  • The candidate must have excellent oral and written communications skills and be able to prepare project reports and make internal and client presentations.
  • Excellent interpersonal skills and ability to work collaboratively as part of a fast paced research team.
  • Experience working in industry is a big plus.

 

SENIOR SCIENTIST PROTEOMICS / PROTEIN CHEMISTRY


Caprion is seeking a highly motivated Senior Scientist with experience in protein chemistry/mass spectrometry/protein characterization to join a collaborative, proteomics focused scientific environment at its site in Menlo Park, California. Caprion’s leading and proprietary proteomics discovery technologies - ProteoCarta® - enable the discovery of novel targets for therapeutics development and the identification of novel protein biomarkers that can significantly reduce risk and enhance clinical development productivity and decision making in pharmaceutical research.

Overview:

The Senior Scientist will be primarily responsible for developing and running MRM-based assays for biomarker quantification using Agilent QQQ systems. He/she will also conduct label-free differential quantification and identification of protein biomarkers using the Thermo QExactive system. Knowledge and experience in sample preparation techniques for mass spectrometry analysis is required. This individual will spearhead study design, method development, data analysis, and reporting. He/she will work independently but closely with proteomics and bioinformatics scientists in a results-driven, collaborative environment. He/she will be responsible for the choice of experimental methodology, the writing of the study plan, carrying out the analyses and providing interpretations and conclusions from the results in a report or scientific manuscript for each project in a timely fashion. The successful candidate will also advise the scientific team on MRM development, platform design, study design, and data analysis.

Responsibilities:

  • Perform and supervise sample preparation for a variety of biological materials.
  • Perform mass spectrometry analysis and interpret results to ensure validity of conclusions.
  • Hands-on experience in operating a variety of electrospray-based LC/MS systems with a high comfort level is required.
  • Provide clear analysis of results and biological interpretation.
  • Write and review study reports and scientific manuscripts.
  • Provide significant input into the design of quantitative clinical proteomic studies.
  • Propose and implement novel quality control and sample or data analysis procedures.
  • Manage or train RAs to perform new sample preparation or analytical techniques.
  • Provide scientific recommendations to improve the quality of results and the platform.
  • Monitor data quality and take responsibility for project execution in the laboratory.

Skills Requirements:

  • Ph.D. in Analytical Biochemistry or related field of study.
  • Five to ten years of work experience in proteomics and/or protein chemistry.
  • Solid understanding of mass spectrometry, molecular biology, protein chemistry.
  • Experience with Agilent QQQ and Thermo QE instrumentation.
  • High level of comfort with troubleshooting, repair, and maintenance of analytical instrumentation.
  • Ability to analyze proteomics data and correlate with biochemistry.
  • Strong written and oral communication skills, including the ability to present research and help write grants or grant reports.
  • Proficiency in use of computer software related to LC-MS and proteomic database searches is desired; minor VBA programming and proteomics data analysis/visualization is a plus.
  • The successful candidate will be self-motivated, highly organized and efficient and be able to work both independently and as part of a team.
  • Must be able to successfully adapt in a rapidly changing environment.
  • Experience working in industry is a plus.
  • Previous publications on biomarker discovery in biological fluids or tissues are a big plus.

 

RESEARCH ASSISTANT, ANALYTICAL / PROTEIN CHEMISTRY


The Position:

Caprion Proteomics USA LLC is seeking a highly-motivated and enthusiastic Research Assistant with an analytical, protein chemistry or engineering background in our facilities in Menlo Park, CA. The successful candidate will be responsible for analytical analysis, instrument maintenance, and general laboratory management activities.

Specific duties:

  • Analytical instrument maintenance (multiple LC-MS/MS including Thermo and Agilent mass spectrometers and HPLC instruments), troubleshooting and repair.
  • General laboratory duties such as buffer preparation, waste management, ensuring laboratory safety and reagent ordering.
  • Routine analysis of proteins and peptides using HPLC and other analytical techniques (mass spectrometry, assays, etc.) and sample preparation while adhering to standard operating procedures (SOPs).
  • Scheduling preventative maintenance of instrumentation.
  • Documentation and communication to senior staff.

Education:

  • Bachelors in Biochemistry, Analytical Chemistry, Chemistry, Biomedical engineering or a related field.

Experience and Skills:

  • Must have at least 2 years of hands-on experience working in a laboratory environment. Experience with analytical techniques and automated or semi-automated instrumentation for the analysis of proteins and peptides is preferred.
  • High level of comfort with troubleshooting, repair, and maintenance of analytical instrumentation. Experience with mass spectrometry desirable but not critical.
  • Practical experience with HPLC and controlling software desirable.
  • The successful candidate will be self-motivated, highly organized and efficient and be able to work both independently and as part of a team.
  • Must have strong problem-solving and communication skills.
  • Must be able to successfully adapt in a rapidly changing environment.
  • Familiarity with general lab practices, lab safety, and modern analytical equipment.
  • Experience with personal computer software and applications such as Microsoft Excel, Word, and PowerPoint.

 

PRINCIPAL SCIENTIST - IMMUNECARTA


ImmuneCarta Services Inc. is seeking a qualified Principle Scientist. The Principal Scientist works independently and acts as a scientific leader in the planning, conduct and management of immune monitoring (IM) projects; Ensures that projects are performed in accordance to clinical protocols, SOP and GLP/GCLP when applicable; Is accountable for overall scientific quality and regulatory compliance of projects; Interacts with clients regarding scientific and general projects issues; Interacts with QA for quality issues; Acts as a key resource person in the mentoring/training of scientific personnel. Represents ImmuneCarta Services at scientific meetings and participates in the preparation of scientific or technical materials (e.g. manuscripts, posters).

The Principle Scientist responsibilities include:

  • Oversees the planning and progress of study/project under her/his responsibility;
  • Designs and prepares detailed study-specific workplans, IM approaches and supporting documentation for IM protocols and assays;
  • Interacts regularly with clients, clinical sites and ImmuneCarta management concerning project issues, and documents properly study-related interactions and communications;
  • Prepares preliminary budget for immune monitoring projects including an assay plan to be reviewed by, and discussed with management and clients;
  • Manages, trains, supervises and mentors laboratory personnel (e.g. research assistants and technicians) working on her/his projects;
  • Ensures that projects are conducted as per preset timelines;
  • Performs analysis of experimental FACS data or supervises such analyses done by laboratory personnel to ensure scientific integrity and compliance with SOP when applicable;
  • Prepares preliminary and final reports and ensures that all study-related data is appropriately maintained and archived;
  • Participates actively in the preparation and conduct of clients or regulatory body audits;
  • Participates in the development of new in vitro assays as per client needs, including the assay validation phase;
  • Provides scientific guidance as a high-quality resource person and contributes to the scientific leadership of ImmuneCarta Services.
  • Approaches work methodically and systematically. Establishes priorities from among a number of demands. Excellent data analysis and interpretation skills;
  • Communicates clearly and confidently and has excellent interpersonal skills. Is fluent in French and English (written & spoken).
  • Must be skilled to work in a high-stress and multi-tasking environment.
  • Performs other duties as assigned.
  • Must accept to perform duties or supervise activities in Bio Safety Level (BSL) 1 or 2 facilities where biological samples may be either naturally or experimentally infected with potentially hazardous viruses such as HIV, HCV, or CMV.

Experience:

  • Ph.D. or equivalent training in life sciences, preferably in immunology, virology, microbiology or molecular biology.
  • A minimum of 3 years post-doctoral experience or equivalent position
  • Knowledge of modern immunology, IM methodologies and clinical trial design and regulations; knowledge of flow cytometry techniques and its generic applications in the field of IM; knowledge of cell-based assays to monitor adaptive and innate immune responses;
  • Knowledge and understanding of GLP regulations and other regulatory guidelines sufficient to carry out GLP studies.

 

ASSISTANT CONTROLLER


Reporting to the Controller, the Assistant Controller is responsible for all the financial records for the company. The Assistant Controller will supervise 2 accounting members to assist him/her with its responsibilities. The Assistant Controller will review, analyze and implement all necessary processes to ensure that accounting records and financial records of the company are consistent with Private Entity Generally Accepted Accounting Principles (PE GAAP).

Responsibilities:

  • Supervise and / or record all accounting entries;
  • Prepare and send customer invoices as well as track accounts receivable;
  • Prepare consolidated monthly multicurrency financial statements;
  • Prepare monthly reports to shareholders, including analysis of variance;
  • Coordinate the preparation of all R & D tax credits and income tax returns for all the companies;
  • Coordinate the preparation of audit files;
  • Create and implement internal control policies and methods;
  • Review and recommend changes to existing accounting practices;
  • Support the company’s information needs and financial analysis;
  • Performs all other requests within its areas of responsibility and expertise.

Qualifications:

  • Member of the Order of CPA;
  • Minimum of 5 years’ experience in consolidating financial statements and supervising staff;
  • Knowledge of R & D tax credits and Great Plains accounting software is an asset;
  • Excellent knowledge of Excel;
  • Bilingual.

 


Interested candidates should submit their résumé by post or by email to:

Human Resources
Caprion
201 avenue Président-Kennedy, suite 3900
Montréal, Québec, Canada H2X 3Y7
careers@caprion.com

Please note, phone calls will not be accepted.  We thank all applicants for their interest, however, only those selected for an interview will be contacted.

© 2014 Caprion