Caprion

Finding proteins that hit the mark

Career Opportunities

Corporate culture

Caprion offers a dynamic and stimulating work environment, encouraging continuous innovation and the sharing of knowledge and ideas. We are proud to have built a strong team of highly motivated and skilled people.

We believe our success depends on the contributions and dedication of each employee. We are looking for individuals who are motivated by challenges and have the skills needed to evolve themselves and the company into the future.

Our world-class proteomics facility is situated within the Science Pavillion building of UQAM (Université de Québec à Montréal) in downtown Montréal.

 
Opportunities

 

DIRECTOR OF BIOINFORMATICS

 

In this role as Director of Bioinformatics (BI), reporting to the Vice-President, Scientific Operations, you will lead Caprion’s bioinformatics/statistics group and will be a team player with leadership skills and experience.

Responsibilities:

  • Overall team supervision ;
  • Team development including individual team member coaching, goal setting, technical mentorship and enforcement of best practices;
  • Developing and implementing workflows as well as tools to process and manage data in an effective and timely manner;
  • Organizing and leading the team to ensure a robust and scalable platform;
  • Developing and implementing training programs for staff to build an environment of high performance;
  • Providing accurate estimation of bioinformatics/statistics effort for projects based on scope of work;
  • Proper allocation of resources to staff projects appropriately;
  • Directing the work of staff applying bioinformatics/statistical tools;
  • Collaborating with Study Directors and Process Leaders to ensure that project objectives are met and are completed on time;
  • Ensuring effective communication within and across teams as well as Caprion sites (Menlo Park and Montreal);
  • Keeping abreast of new bioinformatics/statistical tools and software for proteomic analysis;
  • Recommending new systems and processes to improve current proteomic platform;
  • Testing new and updated bioinformatics/statistical tools and software;
  • Collaborating with software developers in the development and modification of commercial bioinformatics software;
  • Developing and delivering presentations and updates for senior management and Caprion customers;

Requirements:

  • The qualified individual will possess a Ph.D. in Biostatistics, Bioinformatics, Computer Science or related field, along with 5+ years of experience in the Bioinformatics field and 3+ years of direct management experience in life sciences.
  • Direct experience with “Omics” data analysis is an asset and knowledge of biomarkers and clinical drug development is a plus.
  • Works closely with business management and charting a cogent Bioinformatics strategy at the scientific level, including designing the enabling technology/information management solutions and leading their successful execution.
  • You should have the ability to integrate different perspectives and deliver enterprise-wide strategic impact; with a successful track record in a sophisticated technology organization, preferably in a research-intensive and entrepreneurial environment.
  • You need a broad business and scientific perspective, not just technical knowledge;
  • Excellent problem solving abilities, communication and interpersonal skills; a keen ability to lead and motivate and superb management and strategic planning skills.
  • Demonstrated ability to manage multiple short and long-term projects of varying complexity with flexibility in a dynamic environment where priorities are changing.
  • A strong results-oriented work ethic is required to ensure on-time high quality delivery of products to customers.
  • Abilities to build consensus and partnership around issues that help the organization thrive in a competitive biotechnology environment will be put to good use.


BIOSTATISTICIAN - DIAGNOSTICS

 

Caprion is seeking a highly motivated individual with experience in biostatistics and diagnostics. As part of the Caprion Diagnostics group, reporting to the VP of Biomarker Discovery & Diagnostics, the Biostatistician is responsible for multivariable models for diagnostic applications including the selection and documentation of the statistical methodology, study design, data analysis, interpretation and visualization. The successful candidate will also perform ad-hoc analyses and advise the scientific team on general statistical questions, study design, and data analysis.

Responsibilities:

  • Provide significant input into the design of clinical proteomic studies.
  • Write formal Statistical Analysis Plans for complex studies.
  • Create randomization schemes for sample processing.
  • Perform statistical analyses of data (differential expression, classification) and interpret results to ensure validity of conclusions.
  • Propose and implement novel quality control and data analysis procedures.
  • Provide clear visualization and summary of statistical analysis results.
  • Write and review statistical sections for protocols and study reports.
  • Provide scientific recommendations on how to improve the quality of the results and the throughput of the research platform.
  • Perform ad-hoc analysis to evaluate data quality or improve the understanding of the results.

Skills Requirements:

  • Graduate degree in Biostatistics, Statistics, Bioinformatics or related field of study.
  • Three years of work experience in related field.
  • Experience with a variety of statistical methods including general linear models (e.g., ANOVA), logistic regression, univariate and multivariate analyses, and longitudinal analyses.
  • Experience in predictive modeling, classification methods.
  • Experience with R (preferred) or Matlab is an asset.
  • Experience with Perl and/or C++ is an asset.
  • Strong oral and written communication skills.
  • Ability to work collaboratively as part of a fast paced research team.

 

SENIOR SCIENTIST SAMPLE PROCESSING/MASS SPECTROMETRY

 

Caprion Proteomics is seeking a highly motivated individual with experience in protein chemistry/mass spectrometry/protein characterization to join a collaborative, proteomics focused scientific environment. Caprion’s leading and proprietary proteomics discovery technologies - ProteoCarta™ - enable the discovery of novel targets for therapeutics development and the identification of novel protein biomarkers that can significantly reduce risk and enhance clinical development productivity and decision making in pharmaceutical research. Caprion is based in Montreal, Canada (www.caprion.com) and is looking to fill a Senior Scientist position as described below:

The focus will be on conducting label-free differential quantification and identification of protein biomarkers using the Thermo QExactive as well as conducting MRM-based assays for marker verification and validation, using the Ab Sciex QTRAP systems. This individual will work independently but closely with proteomics and bioinformatics scientists in a results-driven, collaborative environment. He/she will be responsible for the choice of experimental methodology, carrying out the analyses and providing interpretations and conclusions from the results in a report for each project in a timely fashion. The successful candidate will also advise the scientific team on general biomarker discovery questions, platform design, study design, and data analysis. The Senior Scientist is expected to propose and implement new sample analysis procedures and/or improve existing ones. You will train RAs to support your biomarker discovery experiments with abundant protein depletion, SCX and High-pH RP chromatography for sample fractionation as well as sample preparation following standard operating procedures.

Responsibilities:

  • Perform sample preparation for a variety of biological materials.
  • Perform mass spectrometry analysis and interpret results to ensure validity of conclusions.
  • Hands-on experience in operating a variety of electrospray-based LC/MS systems with a high comfort level.
  • Responsible for method development both discovery and quantitative method. Ability to also perform method development and validation of PK assay of biomarker(s) and drug products such as biologics/biosimilars
  • Perform in-depth data analysis and interpretation for each experiment
  • Provide clear presentation and summary of analysis results and biological interpretation.
  • Design and execute experimental testing
  • Design and execute troubleshooting experiments
  • Propose and implement novel approaches to sample processing and mass spectrometry analysis.
  • Train Research Associate to perform new sample preparation or analytical techniques.
  • Provide scientific recommendations to improve the quality of results and the platform.
  • Monitor data quality and take responsibility for project execution in the laboratory.
  • Must be capable of working in a GLP environment

Skills Requirements:

  • M.Sc. or Ph.D in life sciences, chemistry or biochemistry (or equivalent).
  • A minimum of 5 years of relevant experience.
  • Prioritize, organize workload and meet deadlines in a fast-paced, changing environment.
  • Capable of supervision for specific projects will be an asset.
  • May require working in BSL2 environment.
  • Solid understanding of mass spectrometry, molecular biology, protein chemistry.
  • The candidate must have excellent oral and written communications skills and be able to prepare project reports and make internal and client presentations.
  • Excellent interpersonal skills and ability to work collaboratively as part of a fast paced research team.
  • Experience working in industry is a big plus.

 

SCIENTIST: PROTEOMICS/PROTEIN CHEMISTRY

 

Caprion Proteomics is seeking a highly motivated individual with experience in protein chemistry/mass spectrometry/protein characterization to join a collaborative, proteomics focused scientific environment. Caprion’s leading and proprietary proteomics discovery technologies - ProteoCarta™ - enable the discovery of novel targets for therapeutics development and the identification of novel protein biomarkers that can significantly reduce risk and enhance clinical development productivity and decision making in pharmaceutical research. Caprion is based in Montreal, Canada (www.caprion.com) and is looking to fill a Scientist position as described below:

The focus will be on conducting label-free differential quantification and identification of protein biomarkers using the Thermo Q Exactive as well as conducting MRM-based assays for marker verification and validation, using the Ab Sciex QTRAP systems. This individual will work independently but closely with proteomics and bioinformatics scientists in a results-driven, collaborative environment. He/she will be responsible for carrying out mass spec analyses in a timely fashion. The Scientist is expected to propose and implement new sample analysis procedures and/or improve existing ones.

Responsibilities:

  • Perform mass spectrometry analysis (Q Exactive/QTRAP) for a variety of biological materials.
  • Hands-on experience in operating a variety of electrospray-based LC/MS systems with a high comfort level is a plus.
  • Propose and implement novel sample analysis procedures in the proteomics area.
  • Provide scientific recommendations to improve the quality of results and the platform.
  • Must be capable of working in a GLP environment

Skills Requirements:

  • B.Sc. or M.Sc. in life sciences, chemistry or biochemistry (or equivalent).
  • Prioritize, organize workload and meet deadlines in a fast-paced, changing environment
  • A minimum of 2 years of relevant experience.
  • Solid understanding of mass spectrometry, molecular biology, protein chemistry.
  • Excellent interpersonal skills and ability to work collaboratively as part of a fast paced research team.
  • Experience of GLP and working in industry is a big plus.

     

BIOINFORMATICIAN

 

Caprion is seeking a highly motivated individual with experience in bioinformatics and proteomics. The Bioinformatician will mainly perform analysis of proteomic mass spectrometry data using commercial and proprietary software. The successful candidate will also be responsible for evaluating sources of protein annotations and mass spectrometry data, testing analysis software and automating processes to streamline the production pipeline. The Bioinformatician will also be responsible for documenting various steps of the research platform, implementing QC procedures and providing scientific recommendations to improve the quality of the results.

Responsibilities:

  • Perform analysis of mass spectrometry data using the Elucidator software.
  • Evaluate protein annotations and proteomics mass spectrometry databases.
  • aUtomate annotation data extraction, parsing, transformation and loading.
  • Develop and improve software modules of Caprion’s research platform.
  • Document the Bioinformatics workflows, software and databases used in Caprion’s analysis pipeline.
  • Propose and implement quality control and data quality monitoring procedures.
  • Provide scientific recommendations on how to improve the quality of the results and the throughput of the research platform.
  • Perform ad-hoc analysis to evaluate data quality or improve the understanding of the results.
  • Provide general bioinformatics and analytical support internally, to the other groups (Sample Processing, Mass Spectrometry).

Skills Requirements:

  • BSc in Bioinformatics, or equivalent (MS level degree preferred).
  • Five years of experience with two years of work experience in proteomics (preferred), genomics or related field.
  • Experience with a scripting language such as Perl, Python or Ruby.
  • Experience with relational databases such as Oracle, SQL Server or MySQL.
  • Ability to effectively use SQL to design queries for extraction of data from Oracle and MySQL databases.
  • Solid understanding of molecular biology, proteomics and mass spectrometry.
  • Strong oral and written communication skills.

 


Interested candidates should submit their résumé by post or by email to:

Human Resources
Caprion
201 avenue Président-Kennedy, suite 3900
Montréal, Québec, Canada H2X 3Y7
careers@caprion.com

Please note, phone calls will not be accepted.  We thank all applicants for their interest, however, only those selected for an interview will be contacted.

© 2014 Caprion