Caprion

Finding proteins that hit the mark

Career Opportunities

Corporate culture

Caprion offers a dynamic and stimulating work environment, encouraging continuous innovation and the sharing of knowledge and ideas. We are proud to have built a strong team of highly motivated and skilled people.

We believe our success depends on the contributions and dedication of each employee. We are looking for individuals who are motivated by challenges and have the skills needed to evolve themselves and the company into the future.

Our world-class proteomics facility is situated within the Science Pavillion building of UQAM (Université de Québec à Montréal) in downtown Montréal.

Opportunities

ProteoCarta:

ImmuneCarta:

Diagnostics:

General:

 

PROTEOCARTA: RESEARCH ASSOCIATE, MASS SPECTROMETRY


Position Summary:

Caprion is seeking a highly-motivated and enthusiastic Mass Spectrometry Research Associate with a strong background in mass spectrometry-based proteomics. This individual will play a key role in the label-free proteomics analysis of various biological matrices as well as quantitative MRM work for protein biomarkers and biologics/biosimilars. The major goals will be to carry out mass spectrometry analyses in a timely fashion, troubleshoot and resolve instrument issues in a GLP environment.

Specific Duties:

  • Analytical instrument operation, maintenance, troubleshooting and repair (Thermo Q Exactive, AB Sciex QTRAP and 6490 Agilent mass spectrometers).
  • Ensuring that system suitability tests meet criteria, filling out worksheets and log books.
  • Providing scientific and technical recommendations to improve the quality of results and the platform.
  • Organizing workload and meeting deadlines in a fast-paced, changing environment.
  • Work performed in a GLP environment.

Education:

  • B.Sc. or M.Sc. in analytical chemistry, chemistry or biochemistry (or equivalent).

Skills Requirements:

  • A minimum of 2 years of relevant experience operating electrospray-based LC/MS systems with a very high comfort level.
  • Excellent understanding of mass spectrometry and protein chemistry, as well as problem-solving and multitasking skills.
  • Must be self-motivated, highly organized and efficient, and be able to work both independently and as part of a team.
  • Must be able to successfully adapt in a rapidly changing environment.
  • Good written communication skills.
  • Experience working in industry is a big plus.

 

PROTEOCARTA: RESEARCH ASSOCIATE, SAMPLE PROCESSING


Position Summary:

Caprion is seeking a highly-motivated and enthusiastic Research Associate for its proteomics sample processing team. This individual will play a key role in performing a variety of techniques such as immuno-depletion, digestion, solid-phase extraction procedures and analysis by High Performance Liquid Chromatography (HPLC) on study samples (e.g. plasma, serum, CSF and other biological fluids) following Standard Operating Procedures (SOP) and Good Laboratory Practices (GLP).

Specific Duties:

  • Process biological samples for analysis by mass spectrometry
  • Execute work as per established procedures or R&D work instructions
  • Participate in troubleshooting
  • Maintain study-related documentation according to GLP and regulatory guidance
  • Monitor the performance of equipment and recording activities in logbooks
  • Perform general laboratory duties
  • Prepare and review documentation for experiments
  • Perform work in a GLP environment and occasionally in a containment level 2 (CL2) environment

Education:

  • B.Sc. or M.Sc. in life sciences, chemistry or biochemistry (or equivalent)

Skills Requirements:

  • A minimum of 2 years of relevant experience;
  • Knowledge of sample processing for proteomics analysis, such as immuno-depletion and digestion techniques is a plus;
  • Knowledge and experience with chromatography-based techniques (eg., operating HPLC instruments) is a plus;
  • Knowledge and understanding of GLP regulations;
  • Excellent time management and organizational skills to meet deadlines in a fast-paced, changing environment;
  • Ability to work independently, autonomously and as part of a team;
  • Skill to accurately test large numbers of samples with reliable repeatability;
  • Good record keeping, attention to details and commitment to achieve good quality work;
  • Experience working in industry is a plus.

 

PROTEOCARTA: SENIOR SCIENTIST - MASS SPECTROMETRY


Position Summary:

Caprion Biosciences Inc. is seeking a highly motivated individual with experience in protein chemistry/mass spectrometry/protein characterization to join a collaborative, proteomics focused scientific environment. Caprion’s leading and proprietary proteomics discovery technologies - ProteoCarta™ - enable the discovery of novel targets for therapeutics development and the identification of novel protein biomarkers that can significantly reduce risk and enhance clinical development productivity and decision making in pharmaceutical research. Caprion is based in Montreal, Canada (www.caprion.com) and is looking to fill a Senior Scientist position as described below:

The focus will be on conducting label-free differential quantification and identification of protein biomarkers using the Thermo QExactive as well as conducting MRM-based assays for marker verification and validation, using the Ab Sciex QTRAP systems. This individual will work independently but closely with proteomics and bioinformatics scientists in a results-driven, collaborative environment. He/she will be responsible for the choice of experimental methodology, carrying out the analyses and providing interpretations and conclusions from the results in a report for each project in a timely fashion. The successful candidate will also advise the scientific team on general biomarker discovery questions, platform design, study design, and data analysis. The Senior Scientist is expected to propose and implement new sample analysis procedures and/or improve existing ones.

Responsibilities:

  • Perform sample preparation for a variety of biological materials.
  • Perform mass spectrometry analysis and interpret results to ensure validity of conclusions.
  • Hands-on experience in operating a variety of electrospray-based LC/MS systems with a high comfort level.
  • Responsible for method development both discovery and quantitative method. Ability to also perform method development and validation of PK assay of biomarker(s) and drug products such as biologics/biosimilars
  • Perform in-depth data analysis and interpretation for each experiment
  • Provide clear presentation and summary of analysis results and biological interpretation.
  • Design and execute experimental testing
  • Design and execute troubleshooting experiments
  • Propose and implement novel approaches to sample processing and mass spectrometry analysis.
  • Train Research Associate to perform new sample preparation or analytical techniques.
  • Provide scientific recommendations to improve the quality of results and the platform.
  • Monitor data quality and take responsibility for project execution in the laboratory.
  • Must be capable of working in a GLP environment

Skills Requirements:

  • M.Sc. or Ph.D in life sciences, chemistry or biochemistry (or equivalent).
  • A minimum of 2 years of relevant experience.
  • Prioritize, organize workload and meet deadlines in a fast-paced, changing environment.
  • Capable of supervision for specific projects will be an asset.
  • May require working in BSL2 environment.
  • Solid understanding of mass spectrometry, molecular biology, protein chemistry.
  • The candidate must have excellent oral and written communications skills and be able to prepare project reports and make internal and client presentations.
  • Excellent interpersonal skills and ability to work collaboratively as part of a fast paced research team.
  • Experience working in industry is a big plus.

 

PROTEOCARTA: BIOINFORMATICIAN / BIOSTATISTICIAN


Position Summary:

Caprion is seeking a highly motivated individual with experience in bioinformatics, biostatistics and proteomics. As part of the Bioinformatics group, the Bioinformatician/Biostatistician is involved in study design, quality control and analysis of proteomic mass spectrometry data, results visualization and reporting. The Bioinformatician/Biostatistican is responsible for the data processing of raw mass spectrometry data, choice of statistical methodology, the writing of the statistical analysis plan, carrying out the analyses and providing interpretations and conclusions that can be derived from the results. The successful candidate will also perform ad-hoc analyses and advise the scientific team on general bioinformatics and statistical questions and data analysis. The Bioinformatician/Biostatistician is expected to propose and implement new quality control and data analysis procedures and/or improve existing ones.

Responsibilities:

  • Provide significant input into the design of clinical proteomic studies.
  • Perform analysis of mass spectrometry data using the Elucidator software, Mascot, OMSSA, X!Tandem, Peptide/Protein Prophet, etc.
  • Evaluate protein annotations and proteomics mass spectrometry databases.
  • Provide biological annotations, and automate their extraction, parsing, transformation and loading from public or in-house databases.
  • Propose and implement novel quality control and data analysis procedures.
  • Provide clear visualization and summary of analysis results.
  • Provide scientific recommendations on how to improve the quality of the results and the throughput of the research platform.
  • Perform ad-hoc analysis to evaluate data quality or improve the understanding of the results.
  • Write formal Statistical Analysis Plans for complex studies.
  • Create randomization schemes for sample processing.
  • Perform statistical analyses of data (differential expression, classification) and interpret results to ensure validity of conclusions.
  • Write and review statistical sections for protocols and study reports.

Skills Requirements:

  • M.Sc. or Ph.D. in Biostatistics, Statistics, Bioinformatics or related field of study.
  • Three years of work experience in proteomics or related field.
  • Experience with a variety of statistical methods including general linear models (e.g., ANOVA), logistic regression, univariate and multivariate analyses, and longitudinal analyses.
  • Experience in predictive modeling, classification and discriminant analysis is strongly desirable.
  • Experience with R, C++, scripting language (PERL, Python, etc.).
  • Experience with relational databases such as Oracle, SQL Server or MySQL.
  • Solid understanding of molecular biology, proteomics and mass spectrometry.
  • Strong oral and written communication skills.
  • Good interpersonal skills and ability to work collaboratively as part of a fast paced research team.

 

IMMUNECARTA: SENIOR PRINCIPAL SCIENTIST


Position Summary:

The role of a Senior Principal Scientist at Caprion Biosciences within the ImmuneCarta unit is responsible for (a) supervision of principal scientist, (b) the overall conduct of studies in different immune-therapeutic area, (c) overseeing experimental testing design using multi-parametric flow cytometry and EliSpot technology (c) interpretation of data, as well as formulating conclusions/recommendations for next steps, (d) ability to present ImmuneCarta capabilities to clients in a compelling way demonstrating value and differentiation as support function to Business Development activities as well as presentation of results to Sponsor and scientific meetings, (e) ensuring that the timelines/milestones of a study are met by proactively assessing foreseeing challenges, (f) assessing impact of deviations and (g) overall quality of the study conduct. The candidate must have experience working in a GLP environment for which the analysis must be conducted in compliance to clinical protocol, SOPs and regulatory requirements.

Education:

  • Ph.D. or equivalent training in life sciences, preferably in immunology, virology, microbiology or molecular biology. Postdoctoral experience is an asset.

Experience:

  • A minimum of 5 years post-doctoral experience or in an equivalent position.

Knowledge:

  • Knowledge of modern immunology and kept abreast with current literature, IM methodologies and clinical trial design and regulations; knowledge and experience with flow cytometry techniques and its generic applications in the field of IM including testing design as well as handling complex data set of multi-color panels; knowledge of cell-based assays to monitor adaptive and innate immune responses;
  • Experience working with FlowJo, Pestle, Spice, Prism and Excel
  • Knowledge and understanding of GLP regulations and other regulatory guidelines sufficient to carry out GLP studies.

Skills:

  • Approaches work methodically and systematically. Establishes priorities from among a number of demands. Excellent data analysis and interpretation skills;
  • Demonstrates and applies advanced level of understanding and analytical skills to interpret data and draw conclusions within the project goals; critical and creative thinker
  • Communicates clearly and confidently and has excellent interpersonal skills. Is fluent in French and English (written & spoken);
  • Skilled at working in a fast-paced and multi-tasking environment;

Key Responsibilities:

  • Supervision of principal scientist(s);
  • Oversees the planning and progress of studies/projects under her/his responsibility;
  • Designs and prepares detailed study-specific workplans and supporting documentation for IM protocols and assays; discusses with management and obtains approval as appropriate;
  • Participates in the development of new in vitro assays as per client needs, including the assay qualification/validation phase;
  • Instructs laboratory personnel (e.g. research assistants and technicians) assigned to her/his projects;
  • Ensures that projects are conducted as per established timelines;delays are communicated in a proactive manner to client(s) with action plan to minimize the delays
  • Identifies resource constraints and inefficiencies and works with management to resolve;
  • Prepares preliminary and final reports. Ensures that all study-related data is appropriately maintained and archived. Participates in the preparation of presentations and publications in collaboration with clients when possible;
  • Interacts regularly with clients, clinical sites and ImmuneCarta management to address project issues in a timely manner and to the satisfaction of the client. Documents study-related interactions and communications properly;
  • Actively participates in the preparation and conduct of audits for clients or regulatory bodies.

 

IMMUNECARTA: PRINCIPAL SCIENTIST


Position Summary:

The role of a Principal Scientist at Caprion Biosciences within the ImmuneCarta unit is responsible for (a) the overall conduct of studies in different immune-therapeutic area, (b) overseeing experimental testing design using multi-parametric flow cytometry and EliSpot technology (c) interpretation of data, as well as formulating conclusions/recommendations for next steps, (d) presentation of results to Sponsor and scientific meetings as well as general presentations as support function to Business Development activities, (e) ensuring that the timelines/milestones of a study are met by proactively assessing foreseeing challenges, (f) assessing impact of deviations and (g) overall quality of the study conduct. The candidate must have experience working in a GLP environment for which the analysis must be conducted in compliance to clinical protocol, SOPs and regulatory requirements.

Education:

  • Ph.D. or equivalent training in life sciences, preferably in immunology, virology, microbiology or molecular biology. Postdoctoral experience is an asset.

Experience:

  • A minimum of 3 years post-doctoral experience or in an equivalent position.

Knowledge:

  • Knowledge of modern immunology and kept abreast with current literature, immune monitoring methodologies and clinical trial design and regulations; knowledge and experience with flow cytometry techniques and its generic applications in the field of immune monitoring including testing design as well as handling complex data set of multi-color panels; knowledge of cell-based assays to monitor adaptive and innate immune responses;
  • Experience working with FlowJo, Pestle, Spice, Prism and Excel
  • Knowledge and understanding of GLP regulations and other regulatory guidelines sufficient to carry out GLP studies.

Skills:

  • Approaches work methodically and systematically. Establishes priorities from among a number of demands. Excellent data analysis and interpretation skills;
  • Demonstrates and applies advanced level of understanding and analytical skills to interpret data and draw conclusions within the project goals; critical and creative thinker
  • Communicates clearly and confidently and has excellent interpersonal skills. Is fluent in French and English (written & spoken);
  • Skilled at working in a fast-paced and multi-tasking environment.

Key Responsibilities:

  • Oversees the planning and progress of studies/projects under her/his responsibility;
  • Designs and prepares detailed study-specific workplans and supporting documentation for immune monitoring protocols and assays; discusses with management and obtains approval as appropriate;
  • Participates in the development of new in vitro assays as per client needs, including the assay qualification/validation phase;
  • Instructs laboratory personnel (e.g. research assistants and technicians) assigned to her/his projects;
  • Ensures that projects are conducted as per established timelines;delays are communicated in a proactive manner to client(s) with action plan to minimize the delays
  • Identifies resource constraints and inefficiencies and works with management to resolve;
  • Prepares preliminary and final reports. Ensures that all study-related data is appropriately maintained and archived. Participates in the preparation of presentations and publications in collaboration with clients when possible;
  • Interacts regularly with clients, clinical sites and ImmuneCarta management to address project issues in a timely manner and to the satisfaction of the client. Documents study-related interactions and communications properly;
  • Actively participates in the preparation and conduct of audits for clients or regulatory bodies.

 

IMMUNECARTA: RESEARCH ASSISTANT III


Position Summary:

Performs multi-parametric flow cytometry assays as per written procedures. Revises and writes procedures (SOP). Prepares and reviews experimental documentation for complex methods. Involved in the validation of multi-parametric assays. Leads all aspects of a given study (reagents, materials, schedule, documentation, etc). Records associated documentation relevant to the tasks at hand as per appropriate SOP and applicable GLP regulations and GCLP guidelines.

Education:

  • B.Sc. or M.Sc.in life sciences, preferably in immunology.

Experience:

  • At least 2 years in a similar position.

Required Expertise and Skills:

  • PBMC isolation and handling;
  • Multi-parametric flow cytometry assays (phenotyping, ICS, CFSE);
  • ELISpot an asset;
  • Working in a GLP/GCLP environment;
  • Organized, rigorous and autonomous in the conduct of their work;
  • Problem-solving;
  • Time management;
  • Knowledge and understating of the English language sufficient to write and carry out procedures and protocols.

Key Responsibilities:

  • Perform multi-parametric flow cytometry experiments;
  • Prepares and reviews required documentation for experimentation;
  • Leads flow cytometry studies (documentation, schedule, reagents, inventories, resources, etc);
  • Participates in the validation of complex methods (multi-parametric);
  • Writes Method SOP;
  • Records associated documentation relevant to the tasks at hand as per appropriate SOP and applicable GLP regulations and GCLP guidelines.

 

DIAGNOSTICS: BIOSTATISTICIAN - DX


Position Summary:

Caprion is seeking a highly motivated individual with experience in biostatistics and diagnostics. As part of the Caprion Diagnostics group, reporting to the VP of Biomarker Discovery & Diagnostics, the Biostatistician is responsible for multivariable models for diagnostic applications including the selection and documentation of the statistical methodology, study design, data analysis, interpretation and visualization. The successful candidate will also perform ad-hoc analyses and advise the scientific team on general statistical questions, study design, and data analysis.

Responsibilities:

  • Provide significant input into the design of clinical proteomic studies.
  • Write formal Statistical Analysis Plans for complex studies.
  • Create randomization schemes for sample processing.
  • Perform statistical analyses of data (differential expression, classification) and interpret results to ensure validity of conclusions.
  • Propose and implement novel quality control and data analysis procedures.
  • Provide clear visualization and summary of statistical analysis results.
  • Write and review statistical sections for protocols and study reports.
  • Provide scientific recommendations on how to improve the quality of the results and the throughput of the research platform.
  • Perform ad-hoc analysis to evaluate data quality or improve the understanding of the results.

Skills Requirements:

  • Graduate degree in Biostatistics, Statistics, Bioinformatics or related field of study.
  • Three years of work experience in related field.
  • Experience with a variety of statistical methods including general linear models (e.g., ANOVA), logistic regression, univariate and multivariate analyses, and longitudinal analyses.
  • Experience in predictive modeling, classification methods.
  • Experience with R (preferred) or Matlab is an asset.
  • Experience with Perl and/or C++ is an asset.
  • Strong oral and written communication skills.
  • Ability to work collaboratively as part of a fast paced research team.

 

COMPLIANCE SPECIALIST


Position Summary:

Caprion is seeking a highly-motivated and enthusiastic Compliance Specialist to join the team. The Compliance Specialist will report directly to the Director of Operations and will provide support as needed to the Operations and Scientific Groups. This role will have day-to-day responsibilities for ensuring Global Compliance to Caprion procedures and study specific protocols. Ensure study data is updated and accurately maintained according to Caprion SOPs and compliance systems.

Provide technology/compliance expertise and guidance to Caprion team members and study directors to ensure the Global Compliance organization processes are fully optimized.

Responsibilities:

  • Works independently to monitor and regularly verify incoming study data to identify data anomalies and assure corrections are made appropriately according to Caprion SOPs.
  • Liaise with Operations and QA to identify the root cause and resolve anomalies; takes a new perspective using existing solutions or creating new solutions.
  • Implement, manage and maintain procedures for study data and report verification, including periodic data verifications and review to ensure report accuracy.
  • Trains staff on procedures and processes to ensure compliance.
  • Create and maintain a collaborative partnership with Operations and QA to ensure scientific team members and analysts are aware of system and process updates that have the potential to impact the quality of data.
  • Implement procedures in partnership with Operations and QA to streamline and improve documentation/QC process.
  • Uses best practices and knowledge to identify opportunities to improve business processes and performance, and advise operations of possible technical solutions.
  • May lead the work for assigned project teams
  • Acts as a resource and trainer for colleagues with less experience

Education:

  • B.Sc. in life sciences (or equivalent)

Education:

  • A minimum of 3 years’ experience in a GLP environment;
  • Thorough knowledge of GLP-GDP regulations;
  • Excellent organizational skills and ability to multi-task to meet deadlines in a fast-paced, changing environment;
  • Ability to work independently, autonomously and as part of a team;
  • The candidate must have strong oral and written communications;
  • Excellent attention to details, process oriented, meticulous and commitment to achieve good quality work;

 


Interested candidates should submit their résumé by post or by email to:

Human Resources
Caprion
201 avenue Président-Kennedy, suite 3900
Montréal, Québec, Canada H2X 3Y7
careers@caprion.com

Please note, phone calls will not be accepted.  We thank all applicants for their interest, however, only those selected for an interview will be contacted.

© 2016 Caprion